Integrated PEEK flow cell.

High precision CNC milled flow cell features 10 mm light path for high precision analysis and less than 2 uL of internal volume for flow resolution. Essi's innovative proprietary technology.

Chemical compatibility.

All wetted materials are highly inert: quartz glass, PEEK, PTFE and fluoropolymers.

High pressure.

The ODcube can withstand up to 50 bar (as standard or up to 300 bar upon request).

High sensitivity, low limit of detection, low noise.

Essi's innovative 16 bit LED-based detection technology in combination with high-precision flow cell allows detection comparable to HPLC detectors...

Small and affordable

...at a fraction of a price and space required.

Low power - 5 VDC

ODcube requires only a USB cable and requires less than 1 W of power. As it can be powered from a laptop PC, ODcube can be integrated into a large range of systems.

Are you working with chromatography, flow chemistry, bioprocessing or microfluidics? With ODcube you can analyse your processes in real time!

ODcube is a flow-throughpocket-size versatile optical detector capable of providing you with real-time data on optical absorption in flow. The system is highly bio- and chemically compatible and features a flow cell with a 10 mm light path and only 2 µL of detection volume. It comes with versatile, easy to use ODread software. Due to the robust design and innovative low power LED and laser technologies the ODcube requires only a USB cable for power and communication, making it ideal for field instrumentation as well as point-of-care applications. The ODcube can be installed into your instrument as we are happy to provide you with the serial communication protocol for effortless OEM integration. The fine-tuned system with 16-bit detection and programmable gain amplification won't let you down!

options and prices

Example: ODcube as a HPLC detector



Certain analytes can't be detected by direct optical detection. In this case, several analytical kits are available on the market that translate the analyte concentration into color intensity. The same analytical kit scan be used with the ODcube: add the reagents into the flow you want to analyze and install the ODcube and enjoy the instantaneous, continuous analysis!


Install ODcube downstream form any kind of chromatographic column to evaluate what is in the effluent. Real time information on the optical properties of effluent is essential for approprate collection of fractions and also allows the evaluation of chromatografy and quantification of separate substances.


Contorling the variables during a chemical synthesis is crucial for the yields and overall performance of the synthetic systems. By installing the ODcube into the system the substrate consumption as well as product yields can be monitored and evaluated uninvasively. The real time nature of the data provided by the ODcube allows precise control of the synthesis, vastly improving the yields and economy of the processes.


Microfluidics is a scientific field that deals with miniaturization of diverse processes, offering advantages in reduced use of reagents, elevated throughput and parallelization. The small volumes within microfluidic devices hinder analytics; by intstalling an ODcube into your microfluidic system, invaluable real time analytical information on processes will be made available with no sample being lost. The extremely low internal volume and long light pathway of ODcube allows for precise, high resolution readouts. No sampling needed.


Is your HPLC lacking in a certain aspect of the analysis? Upgrade it by installing the ODcube into the system! Integration is simple – you can either use the ODread software for the analysis (data can easily be exported into a text or excel file) or take the advantage of the open serial communication protocol and use your own or third party software.


ELISA assays are diverse and versatile analytical tools that allow rapid and simple analysis and diagnostics using simple, portable devices (e.g. Point Of Care Diagnostics). Flow ELISA assays can be applied to perform in-flow analysis and combined with a ODcube to perform precise, real time quantification. Such systems offer low detection limits, high precision and simplicity of operation.


Processes require constant monitoring and analysis for optimal preformance. The ODcube can be mounted onto the efflux from a reactor in order to monitor optical density and concentrations of optically active substances instantaneously, helping you control and evaluate your bioprocesses.



A standard 405 nm ODcube was installed onto a HPCL, downstream from the column. 10 uL of 1 g/L retinal was injected - the signal from the ODcube is shown above.


A custom 405 nm ODcube (shorter light path - 0.5 mm) was installed downstream from a droplet generation microfluidic chip, detecting 100 nL droplets. 

Besides the quantification of a product within a droplet, anomalies in droplet generation (e.g. non-uniform droplet size) can easily be detected.

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